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Scientist leads oral health research
efforts
by Cindy
Abole
Public
Relations
MUSC translational scientist Keith Kirkwood has a dream for
strengthening the level of oral health research on MUSC’s campus.
And like “Field of Dreams” movie character Ray Kinsella, Kirkwood
believes that “if you build it, they will come.”
Dr. Keith Kirkwood
Kirkwood’s aim is to expand and support research in the College of
Dental Medicine by connecting and recruiting talented researchers
through collaborative research opportunities that will improve the
quality of health care for South Carolinians.
In February, Kirkwood replaced Steven London, DDS, Ph.D., former
associate dean for dental research who left MUSC in 2007. A renowned
periodontal clinician, Kirkwood was an associate professor in the
Department of Periodontics and Oral Medicine at the University of
Michigan School of Dentistry. Now he embraces new challenges,
leadership and collaboration potential at MUSC.
“I want to be able to take things that can be utilized where I can see
promise from strong animal models and translate that to patients from
bench to bedside,” said Kirkwood. “I was searching for an opportunity
to grow and create something that can contribute to MUSC’s mission as a
research intensive institution. I wanted to be part of that legacy.
It’s what drives me both as a researcher and educator to do what I’m
doing right now and I’m happy about that. I liked the opportunities
presented here at MUSC.”
Kirkwood fills the shoes of a man who started a program from scratch
and built it.
“Dr. London was able to create a dental research program from almost
nothing and successfully set the stage for oral health research within
the college and throughout campus,” said John J. Sanders, DDS, dean of
the College of Dental Medicine. “I expect Keith to carry it through and
bring more success to our programs.”
Recruiting Kirkwood to MUSC was quite a coup for the university.
“Dr. Kirkwood’s experience and expertise will greatly accelerate the
College of Dental Medicine and university’s Center for Oral Health
Research mission that will improve and impact our knowledge of
diabetes, oral cancer and other diseases,” said Stephen M. Lanier,
Ph.D., associate provost for research and professor of cell and
molecular pharmacology. “Already the college has laid the foundation
for an oral and craniofacial health research center by assembling a
talented team with an outstanding sense of mission. The program was
primed for bringing aboard individuals of Dr. Kirkwood’s caliber.”
Potential and growth
Kirkwood was attracted to the potential of MUSC as an emerging academic
medical center with numerous opportunities for growth. Considered small
compared to other accredited dental education programs around the
country, MUSC’s program has much to offer, said Kirkwood. Construction
of the new 107,000-square-foot clinical education center, scheduled to
be completed in fall 2009, will provide additional lab space and new
equipment and technologies to help with recruitment. As a magnet
investigator, Kirkwood hopes to attract other investigators and new
talent to MUSC.
The six-story building also is expected to allow the school to
expand its dental student population, enhance collaborative research
capabilities and strengthen opportunities for training and clinical
services.
Establishing a research
center
Additionally, Kirkwood has assumed leadership of the Center of
Biomedical Research Excellence (COBRE) for Oral Health grant, which is
establishing the Center for Oral Health Research, a multidisciplinary
and interactive center within the College of Dental Medicine to
coordinate oral health research, intervention and prevention strategies
to improve the oral health for South Carolinians. COBRE and Center for
Oral Health Research will focus on five mentored research projects and
three core resources—administrative, clinical and biostatistics. The
center recently won a five-year grant renewal until 2012.
The college expects Kirkwood to help attain nationally-recognized
status for its oral research program. “I’m positive he’ll have a good
chance of accomplishing this,” Sanders said. “There’s more opportunity
than ever before with current construction of the new James B. Edwards
Dental Clinical building and research space for investigators. He’s an
experienced researcher and a board certified periodontist who
understands both the clinical and research worlds, and is driven to
taking new discoveries and aligning them with the institution’s
direction in translational research.”
Since his arrival in mid-February, Kirkwood has set three research
priorities that relate to inflammation, cell signaling, cancer biology,
tissue engineering and drug discovery. These priorities are improving
head and neck cancer research, strengthening bioengineering research
between MUSC and the state’s top research universities and utilizing
stem cell biology.
For head and neck cancer research, Kirkwood is aligning clinicians and
researchers to create a more integrated head and neck/oral cancer
program.
“We want to integrate our research missions between different colleges
and departments so that our efforts are more intertwined and not
overlooked,” said Kirkwood, whose research has focused on the study of
chronic inflammation, chemotherapeutics and cell signaling.
Since coming to MUSC, he has addressed specific health and community
groups in an oral health project studying the correlation of
oral/systemic health and chronic disease among specific populations,
notably racial minorities.
“We need to provide better population data for interventional studies
and oral health screenings to help identify at-risk populations for
oral cancer. We can break through so many health disparities through
early intervention and prevention efforts,” Kirkwood said. “At MUSC,
we’re trying to bridge basic, clinical and translational sciences
together. It’s a significant mission for any program, especially dental
medicine and those who have been traditionally connected with the
clinical delivery of health care for patients.”
Preparing talent
Meanwhile, Kirkwood and Michael Kern, Ph.D., Cell Biology and Anatomy
associate professor, codirect the Dental Medical Scientist Training
Program (DMSTP) are preparing DMD/Ph.D., students for biomedicine.
DMSTP is open to six, first-and second-year dental students, and is
funded by the comprehensive research training program T32 awards
offered by National Institute for Dental Craniofacial Research. Typical
to T32 programs, the DMSTP also offers NIH-funded post-doctoral
training to attract and recruit individuals interested in pursuing
biomedical research careers. The program, which begins in July, has
selected two post-doctoral candidates and has two slots yet unfilled.
Kirkwood received his dental degree from West Virginia University in
1991. In 1997, he earned his doctorate in oral biology and completed a
molecular biology post-doctoral fellowship in 1999 from SUNY at
Buffalo, where he had also received a periodontics certificate. He has
authored several peer-reviewed papers, abstracts and book chapters on
periodontics and oral health research. He has received numerous grants
and awards, including the 2005 American Academy of Periodontology
Founda-tion’s Tarrson Fellowship, which recognized him as among the
country’s most outstanding academic periodontists.
Friday, June 13, 2008
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